The thought of a little mouse performing the equivalent of running up and down mountains for half a day if they were humans is overwhelming. How is this possible? Well, with genetic modification advancement this is very possible. Take a selection of standard mice, tweak their genetic code a little, complete several generations of selective breeding and amazingly, you too could have a pocket super mouse. Case Western Reserve University School of Medicine and Cleveland Clinic Foundation have undertaken this task to create super mice, and in 2007, “Overexpression of the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) in Skeletal Muscle Repatterns Energy Metabolism in the Mouse” was released (Hakimi, et al, 2007).
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Hakimi, P, Yang, J, Casadesus, G, Massillon, D, Tolentino-Silva, F, Nye, C.K, Cabrera, M.E, Hagen, D.R, Utter, C.B, Baghdy, Y, Johnson, D.H, Wilson, D.L, Kirwan, J.P, Kalhan, S.C, and Hanson, R.W 2007 ‘Overexpression of the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) in Skeletal Muscle Repatterns Energy Metabolism in the Mouse’, The Journal of Biological Chemistry, vol. 282, No. 45, pp. 32844-32855, DOI 10.1074/jbc.M706127200.
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